You should contact your GP if you experience: New or worsening sexual dysfunction , such as reduced libido, erectile difficulties, or problems with arousal or orgasm Unexpected changes in sexual desire that concern you or affect your relationships Symptoms that may indicate hormonal imbalances , such as irregular menstrual periods, breast tenderness, or mood changes Psychological concerns including depression, anxiety, or body image issues that impact your intimate life Seek urgent medical attention if you experience: Severe, persistent abdominal pain (with or without vomiting) Signs of gallbladder disease (pain in upper right abdomen, fever, yellowing of skin/eyes) Sustained vomiting or diarrhoea leading to dehydration Severe or recurrent hypoglycaemia Your doctor can conduct a thorough assessment, which may include reviewing your medication regimen, checking hormone levels, assessing cardiovascular health, and evaluating psychological factors

A comprehensive review in Frontiers in Physiology found that limited physical activity causes large decreases in muscle mass and strength, plus increased tiredness due to changes in muscle metabolism
Journal: S.S. Srinivasan et al. A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety. Science Advances. Vol. 9, December 22, 2023
Market Access Manufacturing capacity, drug pricing, insurance reimbursement, regional expansion At present, Novo Nordisk and Eli Lilly are leading in terms of approved products, clinical evidence, and commercial infrastructure