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Furthermore, both CYP1A1 and CYP1B1 are induced by the THS aerosol and aerosol chemicals such as PAHs (polyaromatic hydrocarbons) are known potent inducers of CYP1A1 and CYP1B1 38 whilst CYP1A1 induction by nicotine has only been anecdotally reported in rats and not reported in humans 39

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