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Yes, most quality air purifiers are specifically designed for continuous 24/7 operation and are tested for long-term safety

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We have a great blog article on the differences between these types of nicotine but, to cut a long story short, there are several indicators that nic salt e-liquids may be more problematic than freebase e-liquids, one of which is the increased volume of flavourings used in nic salt e-liquids when it is known that flavourings are responsible for some of the volatile compounds produced by the vaping process