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Abbreviations ACE2: Angiotensin-converting enzyme 2 Ang-1-7: Angiotensin 1-7 BALF: Bronchoalveolar lavage fluid CAD: Cinnamaldehyde CDC: US Centers for Disease Control and Prevention CO: Carbon monoxide COPD: Chronic obstructive pulmonary disease COVID-19: Coronavirus disease 2019 CS: Cigarette smoke ENDS: Electronic nicotine dispensing systems EVALI: e-cigarette or vaping product use-associated lung injury FDA: Food and Drug Administration GC-FID: Gas chromatography with a flame ionisation detector GCMS: Gas chromatography-mass spectrometry GM-CSF: Granulocytemacrophage colony-stimulating factor HPLC: High performance liquid chromatography HUVEC: Human umbilical vein endothelial cells IL: Interleukin IFN: Interferon KO: Knockout LCMS: Liquid chromatography-mass spectrometry MCP-1/CCL2: Monocyte chemoattractant protein-1 MMP-9: Matrix metallopeptidase 9 nAChR7: 7 Nicotinic acetylcholine receptor NC: Nickelchromium alloy NO: Nitric oxide PG: Propylene glycol RANTES/CCL5: Regulated on activation, normal T cell expressed and secreted ROS: Reactive oxygen species SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 SS: Stainlesssteel atomizer THC: Tetrahydrocannabinol TNF: Tumour necrosis factor- WT: Wild type References Hiemstra PS, Bals R

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Both Le and Mendez are researchers at University of Michigans Center for the Assessment of Tobacco Regulation, supported with funding from the NIH and FDA