Tobacco smoke can induce metalloproteinase MMP-1, an enzyme that can break down collagen, decreasing skin elasticity
Full-Grain Leather durable, softens and develops patina with regular use

of Oral Pathology, Radiology & Medicine The University of Iowa College of Dentistry Pathophysiology of Aphthous Stomatitis: Immunologic Location: nonkeratinized, unattached mucosal surfaces Typically buccal vestibule, lateral or ventral tongue, floor of mouth Heals in a predictable manner Types: minor, major, herpetiform Treatment not usually necessary for the common minor type Precipitating Factors: Primary Prevention Factors: Relate to maintenance of salivary pellicle or impeding the recognition of antigens to the immune system Pharmacotherapeutic Management Choices: Topical Route - Treatment of choice: triamcinolone acetonide rinse - alters course of disease, increases healing rates - Steroid ointments, pastes Systemic Route - Prednisone - for difficult cases, large +/or multiple ulcerations Over-The-Counter Products Inappropriate Chronic Treatment - Cautery agents - do not affect course of disease (Debacterol, silver nitrate, Negatan, laser) - Tetracycline rinses, oral antibiotics etc

Apples are not a known acid reflux trigger