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However, three facts are clear: 1) the G residues are within CpG couples and the associated cytosines are methylated, 2) mutations occur largely on the non-transcribed strand [repair is known to be deficient on this strand (19, 20)], and 3) binding may be unrelated to chromatin structure since the same pattern has been observed in HeLa cells, bronchial cells, and normal human fibroblasts (11)

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