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Pomerleau OF, Flessland KA, Pomerleau CS, Hariharan M (1992)

Impairment of RAAS homeostasis by chronic smoking or nicotine exposure leads to endothelial dysfunction, vascular inflammation, vascular remodeling, and increased arterial stiffness (Oakes et al., 2018)

Previous literature has demonstrated that the prevalence of co-occurring addictions can be high [15], suggesting that studies which consider addiction as only comprising one specific behavior may be limited in ecological invalidity because individuals have more complex and varied histories of disordered behaviors and co-occurrence [17]

When considering both lesions and leaves, the achieved Dice score was 93.21%, demonstrating commendable generalization and adaptability