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According to the most recent GLOBOCAN data, in 2020, there were 2,206,771 new cases of LC and 1,796,144 recorded deaths globally [3]
To reduce the effect of bias, we adjusted observations that did not account for more than five confounders, including age and sex, because they were the significant bias covariates identified by the bias covariate selection algorithm 29 (Supplementary Table 7)
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The risk of side effects increases with the amount and length of time tobacco is used, and the risk is highest for cigarette users
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