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Globally, ~15% of couples of reproductive age are affected by infertility and the distribution of infertility due to male factor ranges from 20 to 70% with the prevalence of male infertility in North America, Australia, and Central and Eastern Europe varied from 4.5 to 6%, 9%, and 8 to 12%, respectively (Agarwal et al

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These results suggest that previously reported responses to smoking, which include toxin metabolism, macrophage recruitment, and squamous metaplasia, are a joint effort conducted across epithelial cell types