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In this decade and the one after it, the initial health reports on the risks and dangers of smoking were put out

However, with federal regulation of e-cigarettes in place and an uncertain future as many remain under premarket review, some vape shops are now shifting to smoke shops (that sell both vape products and other tobacco products and accessories), diversifying their offerings to include a variety of tobacco products and (un- or under-regulated) cannabis-based products as well as kratom, as well as a growing their online retail segment, which can undermine federal, state and local restrictions on product sales in the retail environment, including youth access

[50] A 2012 study found butterscotch flavor was highly toxic with one liquid and two others had a low toxicity