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The term vaping was derived from the word vapour or vape used to refer to the vapours produced when using this device

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Hanna, Department of Medicine, Nineveh college of medicine Biochemistry, Mosul, IRAQ Email: [email protected] INTRODUCTION Cigarette-smoking is a well-known risk factor for atherosclerosis development and its complications including cerebral and cardiovascular diseases(CVD)1,2 through vascular endothelial damage3 that possibly occurs through oxygen free radicals production as superoxide radicals, hydrogen peroxide and hydroxyl radicals.4,5 Several enzymes capable of producing oxygen free radicals including xanthine oxidase, NADPH oxidase, myeloperoxidase, and endotoxin.4,5 As cigarette smoke contains superoxide and reactive nitrogen species that readily react with various biomolecules,1,6-9 it has been hypothesized that some of the adverse effects of smoking may result from oxidative damage to endothelial cells, which results in nitric oxide (NO) shortage.1,10,11 (NO) shortage regulates vascular tone that accelerates insufficiency of coronary artery and vasoconstriction in many different tissues.3,12 Therefore imbalance between oxidants and antioxidants may play an important role in the susceptible smoker.13,14 In addition cigarette smokers have increased inflammatory responses that further enhance their oxidative stress.8,9 Since in humans, uric acid is the most abundant aqueous antioxidant, accounting for up to 60% of serum free radical scavenging capacity15 and is an important intracellular free radical scavenger during metabolic stress including smoking,16,17 therefore , measurement of its serum level reflects the antioxidant capacity.15 The aim of this study is to demonstrate the possible effect of smoking on serum uric acid concentration