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The nicotine then enters the arterial circulation and moves quickly from the lungs to the brain, where it binds to nicotinic cholinergic receptors (ligand-gated ion channels that normally bind acetylcholine)

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Cigarette smoking (nicotine) causes low back pain in the following manner: In reviewing low back disc problems, research has shown that nicotine affects the circulatory system outside the intervertebral disc, as well as cellular uptake rates and metabolite production within the disc