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Side Effects of Vyvanse Even when taken exactly as directed, Vyvanse, as an amphetamine, can trigger a number of adverse physical and psychological side effects, including: High or low blood pressure Raynauds phenomenon Decreased blood flow to the extremities Rapid heartbeat Muscular tics Profuse sweating Blurred vision Nosebleeds Excessive teeth-grinding Dry mouth Abdominal pain Loss of appetite Nausea/vomiting Weight loss Difficulty in urinating Constipation Anxiety Irritability Paranoia People struggling with Vyvanse addiction may continue to use the drug even after experiencing severe side effects