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Studies have shown that elevated levels of xanthine oxidase due to elevated malondialdehyde levels in the serum of smokers may lead to increased synthesis of uric acid

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Note: The relative risk evoked here is evaluated against a reference cigarette, 3R4F developed by PMI: The assessments for the 3R4F cigarette by smoking regimen found as a trivial effect, due to the higher amount of smoke generated per cigarette under HCI conditions, an increased yield of toxicant and higher toxicological activity per cigarette. An interesting aspect of the relative risk evaluation should arise from the comparison of THS 2.2 with regular vaping devices, for example