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The final sample was divided into three groups: the control group, the price treatment group, and the warning label treatment group, with a total sample size of 744 participants (Supplementary file Table S1)
For example, if CMS grants a likely to be in shortage rebate reduction request for a generic Part D rebatable drug that was submitted on August 15, 2024, and that generic Part D rebatable drug is currently in shortage from September 15, 2025, until May 15, 2026, CMS would apply a 75 percent reduction in the total rebate amount for the duration of the applicable period for which the likely to be in shortage rebate reduction request was granted (that is, October 1, 2024, to September 30, 2025), and then would apply the shortages reduction as proposed in 428.301, beginning with a reduction of 75 percent for a generic Part D rebatable drug for the applicable period beginning October 1, 2025
In addition, nicotine salt e-liquids are optimized for cartridge systems, providing a smoother throat hit at higher nicotine concentrations
