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this area has thinner, more permeable mucosa than the lower lip or cheek Dwell time: The longer the pouch stays in place, the more nicotine is released and absorbed up to a point (typically 3045 minutes for most products) Pouch manipulation: Moving the pouch around with your tongue increases saliva contact and speeds up nicotine release, but can also cause more nicotine to be swallowed rather than absorbed buccally Eating and drinking: Acidic beverages (coffee, citrus juice) lower mouth pH temporarily, reducing free-base nicotine availability and slowing absorption Oral hygiene timing: Fresh brushing can temporarily alter mucosal permeability

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