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Nicotine is addictive, and going without cigarettes can cause physical symptoms of nicotine withdrawal

Often, smoking or using smokeless tobacco is associated with triggers particular emotions (e.g., anxiety) or activities (e.g., having a cup of coffee, socializing with friends) that give you the urge to smoke

Tobacco flavors have consistently played a fundamental role in the global vaping market

A large body of literature has demonstrated that such FosB induction in D1-type [nucleus accumbens] neurons increases an animal's sensitivity to drug as well as natural rewards and promotes drug self-administration, presumably through a process of positive reinforcement