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Regul Toxicol Pharmacol 96:127134 Iskandar AR, Titz B, Sewer A, Leroy P, Schneider T, Zanetti F, Mathis C, Elamin A, Frentzel S, Schlage W, Martin F, Peitsch MC, Hoeng J (2017) Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the respiratory tract