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A randomized trial of dual use of tobacco and e-cigarettes (with different flavors) showed a decrease in harmful or potentially harmful biomarkers for polycyclic aromatic hydrocarbons (PAHs such as pyrene) in users of electronic cigarettes, which were reduced by 6269%

The chemical half-life of antioxidants and surfactants might be reduced from days to hours and minutes, respectively, by increasing ozone levels from baseline background quantities (30 ppb) to summer smog conditions (100 ppb) (157)