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27 While head-to-head clinical studies with varenicline have been conducted with the historical cytisine formulation using a 1.5 mg tablet administered in a 25-day downward titration regimen, 2830 no studies, to date, have directly compared varenicline with the novel cytisinicline formulation evaluated in the ORCA program (3 mg tid for 12 weeks), which is currently under regulatory review by the US Food and Drug Administration

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In a country where smoking is so ingrained in daily life, few understand the harmful effects of tobacco use

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