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Similar content being viewed by others Introduction Cigarette smoking has long been established as a cardiovascular risk factor and is the major preventable cause of death and disability in developed and developing countries

"Tobacco companies put their products in colourful boxes next to sugar or something the children can access." Smoking rates are high in Laos, and it is not unusual to see children with cigarettes

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However, upon conformational changes in KEAP1 resulting from the oxidation of cysteine residues, Nrf2 is stabilized and moves into the nucleus, binding the antioxidant-responsive element (ARE) in the promoter region (Figure 4) (Yamamoto et al., 2018)