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The results showed that Sp1 knockdown reduced the inhibitory effect of the miR-125a-5p inhibitor on MLE-12 cell senescence, the expression levels of Sp1 and SIRT1 were reduced, the level of HIF-1 acetylation increased, and the cellular senescence markers p21 and p27 were up-regulated

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Several ships were launched with enough equipment and supplies to give the hundreds onboard a fighting chance - but since the area around far-off Sirius had never been surveyed, no one really knew what to expect