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In addition to impaired pathogen clearance, these macrophages exhibited reduced production of key pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6, which are essential for orchestrating an effective immune response (72)
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State law requires taxes to be paid on any packs not sold to tribe members, but New York suspended attempts to enforce that rule after it prompted unrest on the reservations in the 1990s
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