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Assessment of oxidative stress by quantification of intracellular oxidised and reduced glutathione in bronchial epithelial cells (BEAS-2B) by separate authors reached comparable conclusions albeit after more intensive exposure conditions for the heated tobacco product under investigation (IQOS) (Dusautoir et al., 2021) whilst a second research group reported that changes in intracellular glutathione were significantly less pronounced for the IQOS heated tobacco product than for either a commercially available conventional cigarette or the 3R4F Kentucky Reference cigarette (Wang L et al., 2020)