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The nicotine in cigarettes causes the blood vessels to shrink, reducing the amount of blood able to circulate

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American Tobacco demonstrated this concept by sending physicians a carton of Lucky Strikes and a letter asking whether they thought the cigarettes were less irritating to sensitive and tender throats than other cigarettes. The letter contained some shocking leading sentences that primed physicians to answer positively, including a phrase stating a good many people thought Lucky Strikes were less irritating