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Paracelsus' suggestion that natural symptoms may provide direct evidence leading to a probable diagnosis or classification of a disease, despite a potentially unobservable cause of the illness, was evident in practice by the 17th century when nosology took form

He said for every 10% increase in prices, consumption will drop 13 to 22% among youth

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Eigen, Selforganization of Matter and the Evolution of Biological Macromolecules, Naturwissenschaften 58 (1971), p