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Notably, our results also demonstrate that SIRT1 expression is downregulated under CSE exposure, contributing to the observed Th17/Treg imbalance

is appropriate for the protection of the public health because of, among several key considerations, the potential to reduce nicotine dependence in addicted adult smokers, who may also benefit from decreasing nicotine exposure and cigarette consumption

Treatment options include only supportive therapy (keep the patient clean and healthy)

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