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it was thought to be a case-by-case situation

PMID 16880445

"Carcinogens in Cigarette Smoke"

Michael Siegel, a professor at the Boston University School of Public Health and a career anti-smoking researcher, notes that this obsession with minor differences represents a curious role reversal, with cigarette companies now reminding regulators that "indeed all cigarettes are hazardous and there is no such thing as a safer cigarette." "My opinion is that most, if not all of the substantial equivalence applications involve minor changes that have no substantial bearing on altering the public health significance or impact of the products," says Siegel