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Over time, these sacs can break down so that a person with emphysema might struggle to get enough air, even when at rest

The association between genetic-risk categories, smoking categories, and the combination of genetic and smoking categories (nine categories with low genetic risk and never-smoking as a reference, 12 categories with low genetic risk and no smoking pack-years as a reference) and incident lung cancer were explored using multivariable Cox proportional hazard models