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[iii] Hon Lik himself was a heavy smoker and, concerned about the health effects of cigarettes, began working on a device that would deliver a nicotine hit to users without the actual need to smoke cigarettes

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For example, although EGFR mutations are more common in never-smokers, one-third of lung cancers with EGFR mutations occur in smokers therefore, knowledge of driver mutations and corresponding treatments gleaned from studies of never-smokers may benefit smokers with the disease

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