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In addition, cigarette smoke harbors high levels of acrolein, a recognized toxic compound to the pulmonary cilia, as well as other agents (such as acetaldehyde, formaldehyde and nitrogen oxides) that could indirectly contribute to the mechanism of pulmonary carcinogenicity

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However, in the smoking group, the higher scores related to microbial biofilm formation (PI), increased bleeding (GI), and consequently increased pocket depth were the predictors of pathological developments in response to nicotine in the peri-implant sulcus 44