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Menthol fundamentally alters nicotine receptors, masks the adverse sensory properties of tobacco products (which ultimately may enhance nicotine intake and drive relapse), and alters nicotine metabolism, increasing its bioavailability, according to a 2020 review published in Nicotine & Tobacco Research Adolescent menthol smokers show significantly higher levels of nicotine dependence, tolerance and emotional attachment to cigarettes, compared to non-menthol smoking peers, according to a 2020 study
Acknowledgements This study was supported by Grants from the Industrial Health Foundation (Grant number, N/A), the Japan Society for the Promotion of Science KAKENHI (20H03952), and National Center for Global Health and Medicine (19A1006)
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