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16(Suppl 1): i53i59.

This is illustrated in a study showing that in LPS-induced macrophages, although the rate of glucose consumed was the same as resting macrophages, the rate of lactate produced was much higher, indicating increased glycolysis while suppressing mitochondrial glucose metabolism ( In recent years, the Warburg effect has been linked to inflammatory phenotypes in autoimmune diseases and chronic infectious diseases (including asthma and COPD) as well as cancer, showing that aberrant immune responses and the property of immune cells to divide and proliferate can utilize the same metabolic pathways to provide fuel for increased effector responses (Figure 1)

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