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Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels

Nausea and Vomiting: High doses of nicotine can induce nausea and vomiting, a response seen more often in inexperienced users

And this invention would certainly have taken place, to the great ease as well as health of the subject, if the women, in conjunction with the vulgar and illiterate, had not threatened to raise a rebellion, unless they might be allowed the liberty to speak with their tongues, after the manner of their ancestors

During the Spanish Inquisition, tobacco was known as Devils Weed. James VI and I, King of Scotland and England, produced the treatise A Counterblaste to Tobacco in 1604, and also introduced excise duty on the product