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Source: based on Chang et al, 2020 16 The researchers concluded that although smoking reduction may decrease lung cancer risks by about one-quarter to one-third, the size of risk reduction is not proportional to the reduction in consumption, and the absolute magnitude of lung cancer risk remains high even among those who cut down substantially

Legal supply chains are subject to taxation, traceability, labour and environmental requirements, while illicit operators remain outside those systems, according to the release

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Therefore, evaluating safety and tolerability is crucial in clinical trials