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This research underscores the need for further investigations to clarify misconceptions about e-cigarettes, including their real effects on populations not exposed to tobacco smoke, the impacts of long-term use, the effects of components other than nicotine like flavorings or moisturizers, and their actual effectiveness in smoking cessation (8)

Gray literature sources including ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP), and preprint repositories such as medRxiv, and bioRxiv were searched up to 6 December 2024