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Hence, the effective removal of damaged mitochondria by mitophagy without harming healthy mitochondria is crucial (Table 1)

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70 Mutation Q311X in Parkin hinders the degradation of PARIS (Parkin interacting substrate), leading to massive aggregation of PARIS protein, which in turn inhibits the nuclear translocation signal of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1)-TFEB and impairs mitochondrial degradation