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These increased inflammatory factors and chemokines leads to further infiltration of immune cells into the respiratory tract, resulting in dysfunctions of fibroblasts, goblet cells, and epithelial cells, ultimately leading to emphysema, mucus accumulation, inflammation, and pulmonary fibrosis [52]

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but as the cigar warms up and hits the "sweet spot", the flavor profile evens out and presents some strong yet not overpowering leather / tobacco flavors