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In animal models, negative effects include blood-brain-barrier disruption, neuroinflammation and oxidative stress disbalance, altered epigenetic processes, and deregulated gene expression

First, the pharmacology of nicotine, the primary psychoactive component of tobacco cigarettes, will be discussed including its role in neurotransmission, drug reward pathways, and nicotine dependence [ Pharmacology Cigarette smoke is composed of a complex array of chemical constituents including products such as carboxylic acids, phenols, water, humectants, terpenoids, paraffin waxes, tobacco-specific nitrosamines, (TSNAs), and catechols [ and subunits ( 17, 910

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Dual Vaping Modes: Choose Regular Mode for extended usage or Pulse Mode for intensified flavor