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The nature of the exercise meant significant lacunae remained, leading the research team to acknowledged "a high level of uncertainty of the relative harm of ENDS [electronic nicotine delivery systems] use compared to smoking." With these caveats, they nonetheless produced an overall estimate of relative harm, finding modern e-cigarettes had 33.2% the harm of cigarettes: "This analysis suggests that the use of modern ENDS devices (vaping) could be up to a third as harmful to health as smoking in a high-income country setting." Like Schrodinger's cat

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Regional variation in iron and iron-binding proteins within the lungs of smokers