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more than $300 billion in annual health care expenses." SFATA said the FDA review process will be costly and claimed that there is growing evidence that e-cigarettes are 95 percent less harmful than combustible cigarettes

Additionally, under section 910 draft guidance of the FD&C Act, 29 HPHCs have been outlined in the Premarket Tobacco Products Applications (PMTA) guidance for Electronic Nicotine Delivery Systems (ENDS)

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and (c) document in timely fashion the current status of the use of multiple types of tobacco products (including e-cigarettes)