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Heated tobacco works best when you want something close to smoking and accept hardware dependency

However, the route, speed and amount of nicotine absorption (and subsequent nicotine levels in plasma) are important determinants of the efficacy of ECs to serve as smoking substitutes and of any concerns about nicotine overdose or intoxication

This wasn't too impactful for me, as I was scrambling to meet a deadline and messaging just about anyone with a phone and discernible online trail

Protonated nicotine (18 mg/mL, medium protonation) e-liquid yielded higher nicotine bioavailability than unprotonated nicotine (18 mg/mL) e-liquid (C max , p = 0.0001