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Abbreviations microCT: Micro computed tomography pQCT: Peripheral quantitative computed tomography NFB: Nuclear factor kappaB CS: Cigarette smoking SHS: Second hand smoke CSE: Cigarette smoke extract TSP: Total smoke particulate LPS: Lipopolysaccharide BMD: Bone mineral density AA: Ascorbic acid TRAP: Tartrate-resistant acid phosphatase ALP: Alkaline phosphatase CatK: Cathepsin K CTR: Calcitonin receptor OPG: Osteoprotegerin RUNX2: Runt-related transcription factor 2 OCN: Osteocalcin Col I: Type I collagen OSX: Osterix BSP: Bone sialoprotein OPN: Osteopontin References Miller S

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Beyond diagnosis, smoking exacerbates diabetes-related complications, such as heart and kidney pathologies and circulation disorders leading to severe infections and potential amputations, blindness, and nerve damage

Over time, an individual can develop a tolerance to or dependency on alcohol