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"Smoking is bad for you, no question about it, but if it's a health issue, why aren't you banning all cigarettes?" Al Sharpton, a prominent civil rights activist and a vocal opponent of regulation, asked at an event in 2019

Study author Ludmil Alexandrov said in a statement that before now, we had a large body of epidemiological evidence linking smoking with cancer, but now we can actually observe and quantify the molecular changes in the DNA due to cigarette smoking. Co-author Sir Mike Stratton added that looking in the DNA of cancers can provide provocative new clues to how cancers develop and thus, potentially, how they can be prevented.