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MDM2 and nuclear factor of activated T-cell 1 (NFAT1) dual inhibitor induces MDM2 autoubiquitination and degradation, and represses NFAT1-mediated MDM2 transcription, which can inhibit the growth and metastasis of HCC cells in vitro and in vivo 152

This brings into question the true efficacy of a similar increase in the age of tobacco and raises the more serious health-related question of whether such a change in age of purchase could actually result in an increase in underage tobacco use as minors, in addition to adults who are 18, 19 and 20 years old, look to other sources for acquiring tobacco products

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