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Many marijuana products are becoming increasingly potent with higher levels of THC, which is very concerning. Smoking and inhaling marijuana, regardless of THC content, has been associated with heart muscle dysfunction, chest pain, heart attacks, heart rhythm disturbances, sudden cardiac death and other serious cardiovascular conditions

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Smoking can lower bone density, increasing the risk of osteoporosis and bone fractures

With respect to aerosol generation techniques, current machine-based aerosol generation techniques pose several challenges for assessing different product aerosols because many smoking machines and exposure systems were originally designed for use with combustible tobacco cigarettes and do not easily translate to the standard production of e-cigarette aerosols