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With the cessation of smoking, the risk is reduced, but many years of time are needed to be as same as the risk level of people who quit smoking than the risk in people who have never smoked

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These changes are believed to play a role in the modulation of the inflammatory response in UC, with some studies indicating that smoking can promote the expression of genes that protect against inflammation in the short term, while also inducing detrimental long-term effects 41

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