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One of the first theological cases in opposition to qat was made in the 16th century by Imam Yahya ibn Sharif al-Din who likened the effects of qat to those of marijuana and opium which are prohibited intoxicants in Islam

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Arianna Stassinopoulos asserts, in her biography of Callas as the victim of manipulative men, that 1960 began with the first major crisis of her voice and attributes this to the effect of her emotional state on her singing