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A nicotine/smoking dose-response association has been observed for some bacterial taxa in gut flora, with an increasing mean relative abundance of specific taxa as cigarette packs per day increased 15

Insomnia or Sleep Disturbances: D ifficulty sleeping is a common symptom of tobacco withdrawal, with many individuals experiencing insomnia or disrupted sleep patterns, according to Lape, E

Apart from the fact that in Reals the company will replace the synthetic flavoring additives that most cigarettes contain with non-synthetic flavoring additives, it seems that the natural quality of Reals will consist in their being advertised and promoted as natural

Just be sure to enjoy them in moderation