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6 A 2019 randomised control trial found no adverse events related to either nicotine replacement therapy (NRT) or ENDS but did find that NRT users were more likely to report nausea (37.9% versus 31.3% of ENDS users) while ENDS users were more likely to report mouth or throat irritation (65.3% versus 51.2% of NRT users)

[135] In the UK and the US, an increase in lung cancer rates, formerly "among the rarest forms of disease", was noted by the 1930s, but its cause remained unknown and even the credibility of this increase was sometimes disputed as late as 1950

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